Post-translational Modification Service

What is post-translational modification service？

Post-translational modifications (PTMs) refer to the covalent modifications of polypeptides after they are synthesized, adding temporal and spatial regulation to modulate protein functions. Post-translational modifications (PTMs) are known to be essential mechanisms used by eukaryotic cells to diversify their protein functions and dynamically coordinate their signaling networks. Defects in PTMs have been linked to numerous developmental disorders and human diseases, highlighting the importance of PTMs in maintaining normal cellular states.

Overall Solution

• CD ComputaBio provides PTM computational modeling, which represents another attractive method with its accuracy, speed and convenience.
• CD ComputaBio uses computational models to predict potential PTM sites in proteins, and models the side chain and main chain conformations to reflect changes caused by common PTMs.
• CD ComputaBio have provided calculation-based PTM services to many customers, and it has been proven to be fast and accurate.
• Our goal is to provide computational PTM services to help study the corresponding effects on protein structure, kinetics and binding specificity.

Figure 1. Computational modeling of post-translational modifications.

Why choose us?

• ComputaBio has a mature computational analysis technology platform.
• ComputaBio has a first-class expert technical team, our team is professional and experienced.
• ComputaBio has established a professional after-sales service team to provide customers with efficient, fast and practical solutions.

Our services

Our post-translational modification service has cooperated with many pharmaceutical companies and research institutions. Our team of experts can provide accurate modeling and analysis on the system of interest. CD ComputaBio team has been working in this field for more than ten years and has published his findings in top scientific journals. Our services may improve the understanding of the above-mentioned effects and functional results, promote the rational design of PTM regulation, and ultimately be used to guide structure-based treatments targeting modified protein systems. If you have a need for post-translational modification, please feel free to contact us.

Reference

[1] Wang Y C, Peterson S E, Loring J F. Protein post-translational modifications and regulation of pluripotency in human stem cells. Cell Research, 2014, 24(002):143-160.

[2] Fung T S, Ding X L. Post-translational modifications of coronavirus proteins: Roles and function. Future Virology, 2018, 13(2).

• Fold Recognition Service
• Physico-Chemical Property Measurements
• Cyclic Peptide Structure Prediction Service
• Protein–Ligand Interaction Modeling Service