Antigenic Determinant Prediction

Antigenic determinant: It is a special chemical group with a certain composition and structure on the surface or other parts of an antigenic substance molecule that can specifically bind to its corresponding antibody or sensitized lymphocyte. The antigenic determinant whose structure has been determined is called an antigenic determinant. Here, CD ComputaBio's bioinformatician can offer you antigenic determinant prediction service to meet the specific needs of different customers.

The selected antigenic determinant should meet the following three points:

1. Hydrophilicity: most antigenic determinants are hydrophilic;
2. On the surface of the structure: most antibodies only bind to the surface of the protein;
3. Flexible: Many known antigenic determinants are in the free movement area.
Therefore, generally speaking, the N-terminal and C-terminal of the protein are good antigenic determinant regions.

Overall solutions

CD ComputaBio calculates the surface accessibility, hydrophilicity and flexibility of each amino acid to roughly calculate the antigenic determinant area. The antigenic determinant area should integrate the above three characteristics. The antigenic determinant prediction tool used by CD ComputaBio includes the following five algorithms:

• Chou & Fasman Beta-Turn Prediction
• Emini Surface Accessibility Prediction
• Karplus & Schulz Flexibility Prediction
• Kolaskar & Tongaonkar Antigenicity
• Parker Hydrophilicity Prediction.

Result analysis

The results of antigenic determinant prediction are shown in the form of graphs. The results of different algorithms are represented by curves in different colors, and you can select antigenic determinants by sliding the slider.

Why choose us?

• CD ComputaBio flexibly and comprehensively provide all services related to antigenic determinant prediction.
• Our team works with scientists, quality assurance/quality control professionals and project managers from many pharmaceutical and biotechnology companies and organizations around the world.
• CD ComputaBio has established a professional after-sales service team to provide customers with efficient, fast and practical solutions.

Our services

CD ComputaBio' antigenic determinant prediction service can significantly reduce the cost and labor of the subsequent experiments. Antigenic determinant prediction is a personalized and customized innovative scientific research service. Each project needs to be evaluated before the corresponding analysis plan and price can be determined. If you want to know more about service prices or technical details, please feel free to contact us.

• Antibody Modeling Services
• Antibody Design/Humanization Service
• Antibody Affinity Maturation Service
• Computer-Aided Antibody Screening and Design
• Antibody Reformatting Service
• Antibody Characterization and Analysis