Antibody Docking Service

In the early development of antibody drugs, the identification of antibody-antigen binding epitopes is the basic prerequisite for revealing the pharmacodynamic mechanism of antibody drugs. It is of great significance for the subsequent humanization of antibody drugs and antibody affinity maturation, and can accelerate the process of antibody drug development. The antibody homology modeling algorithm has been relatively mature after more than ten years of development. Now, CD ComputaBio offers antibody docking service to meet the specific needs of different customers.

Overall solutions

CD ComputaBio can accurately predict the structure of a part of the antibody sequence, and using conventional protein-protein docking prediction algorithms, it can quickly analyze some amino acid interactions at the antibody-antigen binding interface.

CD ComputaBio introduces greater freedom in the docking process through the following four aspects:

• CD ComputaBio uses the traditional Ensemble strategy to simulate conformational selection effects;
• CD ComputaBio anti-heavy chain-antibody light chain binding interface sampling;
• CD ComputaBio optimizes the sampling of parts of the anti-weight chain;
• CD ComputaBio minimizes the energy of all CDR Loops.

Algorithm

CD ComputaBio use SnugDock algorithm to provide you with antibody docking service, which can introduce the concept of "flexibility" between the antibody-antigen molecule and the antibody heavy chain light chain interface. By randomly selecting the above sampling strategy, the "induction fit" in the formation of the antibody-antigen complex is truly realized. effect.

SnugDock's algorithm can improve the accuracy of antigen-antibody docking, making the conformation of near-natural complexes more enriched, and reducing the proportion of false positive structures appearing in the top rankings. Although the imported antibody structure is derived from homology modeling, SnugDock can also effectively reduce the impact of structural errors in the antibody homologous model.

Why choose us?

• CD ComputaBio has extensive knowledge and experience in antibody docking service.
• We have collaborated with many biotech companies and many scientists in research institutes. We have rich experience in this area to meet your scientific research needs.
• CD ComputaBio have interdisciplinary efforts of scientists from various fields.
• CD ComputaBio will complete your project on time and efficiently and meet your requirements.
• CD ComputaBio has established a professional after-sales service team to provide customers with efficient, fast, practical and feasible solutions.

Our services

CD ComputaBio provides professional antibody docking service to meet the specific needs of regular customers on time and according to budget. CD ComputaBio relies on world-class technical expertise, we provide customers with the best quality one-stop antibody docking service, including the development of scientific procedures according to different solution needs. Please feel free to contact us for more detailed information, our scientists will tailor the most reasonable plan for your project. If you want to know more service prices or technical details, please feel free to contact us.

• Antibody Modeling Services
• Antibody Design/Humanization Service
• Antigenic Determinant Prediction
• Antibody Affinity Maturation Service
• Computer-Aided Antibody Screening and Design
• Antibody Reformatting Service