Antibody De Novo Design Service
CD ComputaBio is at the forefront of biotechnology services, offering cutting-edge solutions in antibody de novo design. Our team of experts, armed with advanced computational tools and deep biological insights, is dedicated to helping clients achieve their antibody-related research and development goals efficiently.
Introduction to Antibody De Novo Design
Antibody de novo design is a revolutionary approach that enables the creation of novel antibodies from scratch. Instead of relying on traditional methods of antibody discovery, which often involve immunization of animals, this technique uses computational algorithms to design antibodies with specific binding properties. By leveraging knowledge of antibody structure, protein-protein interactions, and immunology, we are able to engineer antibodies tailored to unique targets.
Figure 1. Antibody De novo Design. (Sesterhenn F, et al., 2020)
Our Services
CD ComputaBio provides an extensive array of antibody de novo design services meticulously crafted to align with your distinct research aspirations in the realm of antibody engineering. Our proficient team, composed of seasoned scientists and researchers, is unwaveringly committed to delivering top-notch services.
Workflow of Antibody De Novo Design
Target Definition: Identify the target antigen clearly, determining it as a specific biomolecule related to diseases, biological processes, or diagnostics. If available, obtain its high-resolution structural information.
Computational Design: Select a suitable antibody framework according to the characteristics of the antigen and epitope, considering factors such as antibody format, stability, and compatibility with the target.
In-Silico Validation: Employ computational methods to predict the binding affinity between the antibody and the antigen. Use calculations like MM-PBSA to evaluate the binding free energy, aiming for high affinity.
Result Delivery: Provide you with detailed result, including relevant pictures and data visual results.
Applications of Antibody De Novo Design
Antibody de novo design has emerged as a powerful tool with wide-ranging applications across various fields. It opens up new avenues and possibilities, enabling breakthroughs in multiple areas. Here are some of the key applications:
Our Advantages
Precision-Tailored to Your Needs
Antibody de novo design service offered by CD ComputaBio allows for the precise engineering of antibodies. We design antibodies to bind to specific epitopes on target antigens with high affinity.
Unprecedented Versatility
De novo design approach enables the creation of antibodies against a wide range of targets, including those that are difficult to access using traditional methods.
CD ComputaBio's antibody de novo design service combines computational expertise with biological knowledge to offer a powerful solution for antibody creation. With its numerous advantages, including precision, efficiency, and versatility, our service is well-positioned to meet the diverse needs of the biotechnology and life-sciences industries. If you would like to learn more about our services or receive project recommendations, please contact us immediately.
Reference:
- Sesterhenn F, Yang C, Bonet J, et al. De novo protein design enables the precise induction of RSV-neutralizing antibodies. Science, 2020, 368(6492): eaay5051.
* For Research Use Only.
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