Bispecific Antibody Drugs Design Service
In the ever-evolving pharmaceutical landscape, bispecific antibody drugs have emerged as a beacon of hope for treating complex diseases, CD ComputaBio offers you an innovative solution-the bispecific antibody drugs design service. Our service is at the vanguard of this innovative wave, presenting all-encompassing and cutting-edge solutions, thus promoting the development of novel therapeutic approaches and the formulation of drug design strategies.
Introductions to Bispecific Antibody
Bispecific antibody (BsAbs) is an artificial protein that can simultaneously bind to two different types of antigens or two different epitopes on the same antigen. Naturally occurring antibodies usually target only one antigen. Bispecific antibodies can be produced in a variety of structural forms. BsAbs can be designed to recruit and activate immune cells, interfere with receptor signaling and inactivate signaling ligands, and force protein complex binding.
Computational Design of Bispecific Antibody
Technologies in computational biology have made the computational design of bispecific antibodies possible. Starting with obtaining antigen structural information, and then using techniques such as molecular docking to screen virtual antibody sequences to find high-affinity binders, techniques such as molecular dynamics and machine-learning algorithms provide powerful tools for constructing effective single-domain antibodies.
Figure 1. Mechanism and structure of different types of BsAbs. (Khosla A A et al., 2023)
Our Services
CD ComputaBio offers professional bispecific antibody drugs design services that are designed to meet your unique research needs in the field of antibody engineering, including but not limited to:
Bispecific Antibody Fragments Design Service
The disease-related antigen structure is first analyzed, and then the antibody fragment database is screened using computational algorithms and molecular docking and molecular dynamics simulation technology. We identify and then construct high-affinity fragments for both antigens, optimizing the sequences to ensure folding, stability, and binding specificity to meet the client's therapeutic or diagnostic needs.
Bispecific Antibody Linker Design Service
CD ComputaBio designs and optimizes linker sequences to connect your antibody fragments, ensuring proper spatial orientation, flexibility, and stability of the bispecific antibody. For targeted drug delivery, we incorporate protease-cleavable linkers that release therapeutic payloads specifically at the disease site. Furthermore, we facilitate site-specific conjugation of your bispecific antibody to drugs, toxins, or other functional moieties, providing precise control over the final construct and enhancing therapeutic efficacy.
Bispecific Design Optimization Service
CD ComputaBio generates high-resolution 3D models of your bispecific antibody to assess structural stability, identify potential aggregation hotspots, and guide optimization strategies. We predict and mitigate immunogenicity risks by identifying and removing T-cell epitopes from the antibody sequence. Additionally, we optimize codon usage and other factors to enhance expression yield and solubility in your chosen expression system, ensuring efficient production and high-quality bispecific antibodies.
Methods of Bispecific Antibody Design
Bispecific antibody drug design services can save manpower and time compared to experiments and can be applied in many fields. The following are the methods we use to support antibody design:
Our Advantages
Expert Team
CD ComputaBio is composed of seasoned scientists with in-depth knowledge in antibody engineering, immunology, and drug development. Their combined expertise allows us to approach each project with a high level of scientific rigor and innovation.
Advanced Technology
By leveraging the latest computational tools for antibody design, high-throughput screening platforms, and state-of-the-art in-vitro assay techniques, we ensure the highest quality results in a timely manner.
One-Stop Solution
Comprehensive service portfolio is provided to clients with a one-stop solution for all their bispecific antibody drug design and development needs.
CD ComputaBio's bispecific antibody drugs design service offers a wide range of solutions for researchers. We utilize the most advanced algorithms and simulation methods to provide customized simulations, comprehensive data analysis, and professional consultation services. If you are interested in our services or have any questions, please feel free to contact us.
Reference:
- Khosla A A, Jatwani K, Singh R, et al. Bispecific antibodies in lung cancer: a state-of-the-art review. Pharmaceuticals, 2023, 16(10): 1461.
* For Research Use Only.
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