Vascular endothelial growth factor (VEGF), a highly specific pro-vascular endothelial cell growth factor, promotes increased vascular permeability, extracellular matrix degeneration, vascular endothelial cell migration and angiogenesis. The concept that tumor growth beyond 2 mm is heavily dependent on angiogenesis has been proposed. Tumors, including colorectal cancer, release angiogenic growth factors that stimulate blood vessels to grow into the tumor, thereby providing oxygen and nutrients for exponential growth, and VEGF is the most potent angiogenic growth factor. The role of VEGF in colorectal cancer, especially in stimulating angiogenesis. Research strongly supports this role of VEGF, and studies have shown that inhibition of VEGF using blocking antibodies results in reduced angiogenesis and elimination of cancer growth. Now, CD ComputaBio offers professional VEGF targeting services to meet your research needs.
Our Services
- Molecular Dynamic Simulation
Molecular dynamics simulations are used to predict changes over time in systems containing proteins, DNA/RNA, lipids and other small ligands to explore important biological and pharmaceutical events. Specifically, it can be used to identify hidden or metastable binding sites, enhance traditional virtual screening methods, and directly predict the binding energy of small molecules. Our MD results analysis include:
- RMSD Analysis
- Residue Correlation Analysis
- Energy Decomposition
- Binding Mode Analysis
- Hydrogen Bond Analysis Service
- Hydrophobic Interaction Analysis Service
- Virtual Screening
Virtual screening is used to rapidly screen active compounds with drug-forming properties from tens to millions of molecules, and molecular docking operations between small molecules and drug targets greatly reduce the number of compounds to be experimentally screened and shorten the research cycle. The virtual screening methods we use are divided into two main types:
- Structure-based Virtual Screening (SBVS)
- Ligand-based Virtual Screening (LBVS)
- Network Analysis
Biological network analysis is used for target analysis, and network analysis is widely used to analyze the topology and dynamics of complex systems. We offer both residue interaction network service and PPI network service, which can better help you to perform target analysis.
- Bioinformatics Services
The use of bioinformatics can help to mine and interpret the vast amount of biological data generated in the recent boom in high-throughputomics research. Our computational biology platform is equipped with advanced computational instrumentation and software, and our scientists can provide the following services.
- Gene Function Annotation and Function Enrichment Analysis service
- Bioinformatic Analysis-Data Preprocess and Normalization Service
- Bioinformatics Data Management Service
Our Capabilities
CD ComputaBio has substantial expertise and experience in target research involving drug design, molecular docking, molecular dynamics simulation and other methods. We have established a comprehensive and sophisticated computational platform. Our mission is to provide reliable and high-quality services that strongly support our clients in target analysis, prediction and evaluation.
Our Antibody Drug Discovery Strategies Targeting VEGF
- Antibody Reformatting Service
CD ComputaBio can reformat antibodies and antibody fragments into virtually any format. The antibody variable region genes (VH and VL) from a given antibody can be reformatted to encode different constant regions, including Fab.
- Antibody Modeling services
We first searched for framework antibodies (FR) from the template database, which is derived from publicly available crystal structures in the Protein Data Bank (PDB). Thereafter, templates for the CDR region are selected from typical ring conformations aggregated in the database based on homology. Then, with the refinement of the H3 ring, the structure of the Fv region is modeled. The entire antibody including the constant region (Fc) can also be modeled.
Project Sample
Our computational biology team has extensive experience in the research of VEGF targets. The following is a small snapshot of our research process for reference only. For details, please feel free to consult our professional team.
* For Research Use Only.
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