The TAU protein is a set of six highly soluble protein isoforms by generating alternative splicing from the gene MAPT (microtubule-associated protein TAU protein). They have axons that mainly act to maintain stable microtubules and are in the central nervous system (CNS), which is abundant in neurons. They are less common elsewhere, but in CNS astrocytes and oligodendrocytes. Pathology of the nervous system and dementia, such as Alzheimer's disease and Parkinson's disease are related to TAU protein.
With signs of dementia, if clinicians find a combination of amyloid plaques and neurofibrillary tangles in the brain, then a clear diagnosis of Alzheimer’s disease can be made. Plaques are accumulations of amyloid peptides. The tangles are mainly composed of a protein called TAU. A key but difficult to detect difference in the form of the TAU protein can help scientists distinguish between those with no external signs of dementia and those with dementia.
Our Services
- Provide molecular design and high-throughput screening of TAU protein inhibitors.
- Provide structural optimization and energy minimization of TAU protein inhibitors.
- Build a target detail-observation (PPI) network.
- Gene Ontology (GO) and KEGG Topic Enrichment Analysis.
- Construct a "target-signal" network diagram.
- Molecular docking verification core target.
- Provide relevant molecular dynamics simulation and result analysis.
- Provide related result analysis service.
- Use statistical techniques to process data and analyze results.
Provided by Clients
Please inform us of the details about your TAU targeting research project after signing a non-disclosure agreement, which can be specific to the force field of molecular dynamics simulation, and the result analysis requirements.
Deliverables
- The original structure of designed TAU inhibitors
- High-throughput screening and structure optimization results
- PPI network results analysis
- Gene Ontology (GO) results analysis
- KEGG topic enrichment results analysis
- Raw data of molecular dynamics results
- Other calculation and analysis results
Our advantages
- CD ComputaBio has professional computational experts. You only need to briefly describe your service needs, and our experts will provide you with customized solutions.
- Our team has deep scientific literacy and years of experience in the industry, and can bring more profound and in-depth professional knowledge and rich experience to customers.
- We have strict quality control on every step of computing service to ensure that our customers get high-quality data.
If you want to know more about TAU targeting services provided by CD ComputaBio, please contact us at any time.
Reference:
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Evan E. Hubbard, Lilian R. Heil, Gennifer E. Merrihew, et al. Does Data-Independent Acquisition Data Contain Hidden Gems? A Case Study Related to Alzheimer's Disease, Journal of Proteome Research (2021).
* For Research Use Only.
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