CD ComputaBio now offers professional PTK7 targeting services using computational approaches to meet your research needs.
Protein tyrosine kinase-like 7 is a receptor tyrosine kinase encoded in humans by the PTK7 gene. Receptor protein tyrosine kinases transduce extracellular signals across cell membranes. A subset of these kinases lack detectable catalytic tyrosine kinase activity but retain a role in signal transduction. The protein encoded by this gene is an intracellular domain with tyrosine kinase homology and functions as a cell adhesion molecule. This gene is thought to be expressed in colon cancer, but not in normal colon, and thus may be a marker of tumor progression or may be involved in tumor progression. Four transcript variants encoding four different isoforms have been identified for this gene. PTK7 acts as a context-dependent signaling switch for the Wnt pathway and appears to have similar functions for the plexin and Flt-1 pathways.
Our Services
- Enzyme Molecular Dynamics Simulation Service
Molecular dynamics simulation was used to predict changes in the PTK7 enzymatic system over time, thereby exploring important interaction informative details. Specifically, experimentally determined structures can be refined, enzyme-ligand binding assessed, and ligand-enzyme interactions studied. MD simulations are particularly useful in computer-aided drug discovery. It can be used to identify cryptic or allosteric binding sites, enhance traditional virtual screening methods, and directly predict the binding energies of small molecules. The steps of our enzyme molecular dynamics simulation are as follows:
- ADMET Prediction Service
We provide you with ADMET prediction services using computer-aided methods, our experts use project data or published data to predict ADMET properties of new compounds. We can also estimate these properties using ADMET QSAR models built by software vendors. The main functions of ADMET services are as follows:
- PTK7 inhibitor design service
We provide design services for PTK7 small molecule inhibitors, and we also provide design services for peptide inhibitors. For designed compounds, we offer further structural optimization and screening services. We provide inhibitor molecular docking (PTK7-small molecule inhibitor docking and PTK7-peptide inhibitor docking) and molecular dynamics simulation services to select appropriate simulation conditions such as molecular dynamics simulation force fields for you.
Our Capabilities
CD ComputaBio offers you a variety of target analysis service types to choose from. Our experts have extensive experience in the field and have successfully completed several projects. We will complete your project on time and efficiently. Our researchers can quickly understand the project situation through a simple description, and quickly develop a feasible research plan according to customer needs. If you would like to know more about the PTK7 targeting services provided by CD ComputaBio, please feel free to contact us.
Our Computational Peptide Services PTK7
We provide professional computational peptide services. In addition to designing small molecule inhibitors for you, we can also provide peptide inhibitor design services, subsequent peptide molecular dynamics simulation and result analysis services. Specifically, our computational peptide services include, but are not limited to:
* For Research Use Only.
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