Protein arginine N-methyltransferase 5 is an enzyme encoded by the PRMT5 gene in humans.PRMT5 symmetrically dimethylates H2AR3, H4R3, H3R2, and H3R8 in vivo, all of which are associated with a series of transcriptional regulatory events.PRMT5 is a highly conserved arginine methyltransferase that is transferred from the cytoplasm to the nucleus during pre-implantation development at embryonic ~E8.5 and ~4 cell stages. development from the cytoplasm to the nucleus.PRMT5 has been shown to interact with CLNS1A, RIOK1 and COPR5 by bridging the protein through a shallow groove located on the TIM barrel structural domain of PRMT5 and a shared sequence GQF[D/E]DA[E/D] created at the terminal region. CD ComputaBio now offers professional PRMT5 targeting services to meet your research needs.
Our Services
- Molecular dynamics simulation
We provide molecular dynamics simulation and molecular docking services between inhibitors and pre-defined proteases. Subsequently, we provide related result analysis services. We will process the data and analyze the results using statistical techniques.
- Multi-target inhibitor design
CD ComputaBio provides you with multi-target inhibitor design services. The advantage of multi-target drug design technology is to provide new ideas for new drug development, making full use of the structural information of known compounds. For the above inhibitors, we will screen out a series of advantageous ligands for you through virtual screening and structural optimization.
- SAM Services
CD ComputaBio assigns a score to each gene based on the change in gene expression relative to the standard deviation of repeated measurements for that gene. Genes with scores above a threshold are considered potentially significant. CD ComputaBio can adjust the threshold to identify smaller or larger groups of genes and calculate the FDR for each group. because the data may not follow a normal distribution, CD ComputaBio uses non-parametric statistics in this analysis.
Our Capabilities
CD ComputaBio has substantial expertise and experience in target research involving drug design, molecular docking, molecular dynamics simulation and other methods. We have established a comprehensive and sophisticated computational platform. Our mission is to provide reliable and high-quality services that strongly support our clients in target analysis, prediction and evaluation.
Our ADMET Prediction Strategies Targeting PRMT5
CD ComputaBio provide you with ADMET prediction services using computer-aided methods, our experts use project data or published data to predict ADMET properties of new compounds. We can also estimate these properties using ADMET QSAR models built by software vendors. A variety of computer models and massive pharmacology databases were used to accurately predict these properties, using project data or published data to construct QSAR and other models and predict the ADMET properties of new compounds, thus helping researchers eliminate molecules with poor ADMET properties and significantly reducing R&D costs. The main functions of ADMET services are as follows:
* For Research Use Only.
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