PGC1α Targeting Services

Peroxisome proliferator-activated receptor-γ coactlvator-1α (peroxlsome proliferator-activated receptor-γ coactlvator-1α, PGC-1α) is a nuclear transcription co-activator discovered in recent years, which can interact with transcription. The interaction of factors or other co-activators increases the transcription efficiency of target genes through different mechanisms, thereby playing a role in a series of energy metabolism processes such as the body's adaptive heat production, mitochondrial biosynthesis, liver gluconeogenesis and fatty acid β oxidation. Therefore, PGC-1α has become a new hot spot in the occurrence and treatment of metabolic diseases such as obesity and diabetes.

Existing reports have confirmed that the pathogenesis of AD may be closely related to mitochondrial dysfunction. Under physiological and pathological conditions, mitochondria can maintain mitochondrial homeostasis through mitochondrial biogenesis. Therefore, researchers anchored their eyes on PGC-1α, which is possible to regulate mitochondrial biogenesis and maintain mitochondrial protein levels by interacting with multiple transcription factors.

Our Services

• Provide a variety of molecular dynamics simulation services, including all-atom molecular dynamics simulation, umbrella sampling simulation service, steered molecular dynamics (SMD) service, replica exchange molecular dynamics (REMD) services, targeted molecular dynamics (TMD) simulation and coarse-grained dynamics simulations.
• Provide corresponding peptide agonist/inhibitor design services, including peptide homology modeling service, peptide amino acid interaction network analysis, peptide binding affinity calculation service and peptide energy calculation service.
• Provide pathway and network analysis services, CD ComputaBio will construct a signaling pathway regulatory network based on the mutual regulatory relationship between pathways, and study the signal transduction and regulatory processes between various signaling pathways from a systematic perspective. We can find the core pathways and regulatory mechanisms between important signal pathways that are affected by the experiment.
• Provide professional univariate analysis services, including but are not limited to volcano plot service, correlation analysis service, fold change analysis, T-test service and SAM Service.

Provided by Clients

Please inform us of the details about your PGC1α targeting research project after signing a non-disclosure agreement, which can be specific to the details of molecular simulation and the requirements for result analysis.

Deliverables

• Raw data and result analysis of molecular dynamics results
• Raw data and result analysis of peptide molecular dynamics results
• Other calculation and analysis results
• Picture files (Network diagrams), including png, PDF formats.
• Cytocape file: which can be opened by cytoscape for detailed adjustment
• Text file: The relationship between pathways and the indegree and outdegree corresponding to each pathway.
• Related univariate analysis results, including frequency distribution table, bar graph, histogram, frequency polygon and pie chart.

Our advantages

If you want to know more about PGC1α targeting services provided by CD ComputaBio, please contact us at any time.

Reference

1. Panes J D, Godoy P A, Silva-Grecchi T, et al. Changes in PGC/SIRT1 Signaling Impact on Mitochondrial Homeostasis in Amyloid-Beta Peptide Toxicity Model. Frontiers in Pharmacology, 2020, 11:709.

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