Peptide Modification Service
Peptide modification is a powerful strategy to enhance the stability, activity, and specificity of peptides for therapeutic and industrial applications. CD ComputaBio's peptide modification service leverages advanced computational tools and expertise to design and optimize modified peptides, enabling the development of highly effective biomolecules tailored to specific needs.
Introduction to Peptide Modification
Peptide modification is an important process in biochemistry that involves artificially adding or changing molecules to a peptide. This modification is crucial because it can enhance the functionality of the peptide, such as improving its biological activity, stability, and solubility. By doing so, the peptide is better able to perform specific tasks. For example, in the medical field, modified peptides can be used in drug development to improve the efficacy of drugs.
Figure 1. Computational analysis of peptide-brush polymers with varying polymer. (Albanese K I, et al., 2024)
Advantages of Computational Peptide Modification
Precision
Computational tools allow for targeted modifications, ensuring minimal disruption to peptide function while maximizing desired properties.
Efficiency
Virtual screening and modeling reduce the time and cost associated with experimental trial-and-error approaches.
Customization
Tailored modifications can be designed to meet specific therapeutic or industrial requirements.
Our Services
A range of peptide modification services are offered by CD ComputaBio to cater to various research and industrial needs. These services are designed to provide tailored solutions that enhance peptide performance and functionality.
- Peptide Cyclization Services
Cyclization is a common modification that improves the stability and bioavailability of peptides by forming a ring structure. CD ComputaBio uses computational tools and algorithms to determine the most effective cyclization strategy to ensure that the resulting peptide retains its biological activity while improving resistance to enzymatic degradation.
- Peptide Phosphorylation Services
Phosphorylation plays a crucial role in regulating protein function and signaling pathways. Our phosphorylation services focus on introducing phosphate groups to specific amino acids within a peptide sequence. Computational models are used to predict optimal phosphorylation sites and assess the impact on peptide function, facilitating the design of peptides with enhanced regulatory capabilities.
- Peptide Biotinylation Services
Biotinylation is the process of attaching a biotin molecule to a peptide, which can be used in a variety of detection and purification applications. The biotinylation services we offer use computational tools to identify the optimal attachment site, ensuring that the biotinylated peptide retains its binding affinity and functionality.
- Peptide PEGylation Services
PEGylation involves the attachment of polyethylene glycol (PEG) chains to peptides to improve their solubility, stability, and circulation time in the body. We utilize computational methods to determine the optimal PEGylation sites and configurations, ensuring that the modified peptide retains its therapeutic effects while benefiting from the advantages of PEGylation.
Peptide Modification Services for Different Targets
Our peptide modification services are tailored to target-specific requirements, ensuring optimal peptide performance for your application:
| Targets |
Descriptions |
| Receptor-Targeting Peptides |
Enhance binding affinity and selectivity for GPCRs, ion channels, and other membrane receptors. |
| Protein-Protein Interaction (PPI) Inhibitors |
Modify peptides to disrupt or stabilize PPIs involved in disease pathways. |
| Diagnostic Peptides |
Add fluorescent, radioactive, or biotinylated tags for imaging and detection. |
| Enzyme-Targeting Peptides |
Optimize peptides for enzyme-substrate interactions or transition state stabilization. |
Key Modification Strategies
Chemical Modifications
N- or C-terminal modifications (e.g., acetylation, PEGylation).
Side-chain modifications (e.g., phosphorylation, glycosylation).
Non-Natural Amino Acids
Incorporate D-amino acids, β-amino acids, or other synthetic analogs to enhance stability and activity.
Conjugation
Attach functional groups (e.g., lipids, carbohydrates) to improve pharmacokinetics or targeting.
Peptide modification is a vital process in enhancing the functionality and stability of peptides for various applications. CD ComputaBio offers a robust framework for optimizing these modifications, providing significant advantages in terms of precision, efficiency, and cost-effectiveness. If you are interested in our services or have any questions, please feel free to contact us.
Reference:
- Albanese K I, Petrenas R, Pirro F, et al. Rationally seeded computational protein design of ɑ-helical barrels. Nature Chemical Biology, 2024, 20(8): 991-999.
* For Research Use Only.
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