Nitric oxide synthase is an enzyme encoded by the NOS2 gene in humans and mice. Nitric oxide synthase is expressed in epithelial cells of the liver, lung and bone marrow. It is induced by a combination of lipopolysaccharides and certain cytokines. Nitric oxide is a reactive free radical that mediates neurotransmission, antibacterial and antitumor activity. The immune function of NOS2 against many viruses, bacteria, fungi and parasites has been well characterized in mice, while in humans the role of NOS2 remains elusive and controversial. Nos2 is important for protective immunity against CMV. CD ComputaBio now offers professional NOS2 targeting services to meet your research needs.
Our Services
- Post-translational Modification Service
CD ComputaBio offers PTM computational modeling, which represents an attractive alternative approach with accuracy, speed and convenience. We use computational models to predict potential PTM sites in proteins and model side chain and backbone conformations to reflect changes caused by common PTMs. CD ComputaBio has provided computationally based PTM services to many clients and has proven to be fast and accurate.
- Univariate Analysis
Univariate analysis is probably the simplest form of statistical analysis. Univariate analysis is common in statistical analysis and involves only one variable. The results of the analysis are descriptive or inferential, so the analysis is widely used to analyze data collected from proteomics or metabolomics. The data are usually multidimensional, with the number of features (peaks, metabolites) ranging from tens to hundreds or even thousands. The features of the collected data represent a snapshot of the global biochemical profile of each organism. Most of these features are expected to be within the normal physiological range, and some may fluctuate dramatically due to changes in physiological conditions.
- Computer Aided Drug Design
The computer-aided drug design services we provide are based on computational chemistry, a method to design and optimize lead compounds through computer simulation, prediction and budgeting of the relationship between small molecule compounds (inhibitors) and ROS1. Service details generally include active site analysis, database searches, and molecular docking.
Our Capabilities
CD ComputaBio offers you a complete range of NOS2 targeting services. We have established a complete and professional computing platform. We can help design the details of NOS2 targeting services through rigorous quality control and advanced computational platforms.
Our Network Strategies Targeting NOS2
Residue Interaction Network Services
Our RIN analysis service can provide complex analysis of NOS2 targets. The estimation of their interdependencies can predict the different properties and functions of individual residues and whole proteins. We construct RINs to analyze the energy of target and small molecule compound interactions.
CD ComputaBio offers PPI network analysis to help you gain insight into the details of peptide inhibitor or protein drug interactions with NOS2 targets. PPI network analysis is the creation of highly specific physical contacts between two or more protein molecules, and these interactions include electrostatic, hydrogen bonding, and hydrophobic interactions. This can enhance existing knowledge about the biochemical cascade and molecular pathology of disease and can lead to the identification of therapeutically meaningful targets.
* For Research Use Only.
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