N-Methyl-D-Aspartate (N-Methyl-D-Aspartate, NMDA) receptor is an important subtype of excitatory ionotropic glutamate receptor, which has high permeability to calcium ions. NMDA receptors can regulate synaptic transmission and synaptic plasticity. NMDA receptors mainly mediate the dynamics and plasticity of postsynaptic currents. The opening of NMDA receptor channels requires membrane potential depolarization, release of blocker magnesium ions, and binding of glutamate and glycine. NMDA receptors usually consist of two essential GluN1 and two variable GluN2 (2A-2D) or GluN3 (3A-3B) subunits. The different gate opening mechanism, biophysical and pharmacological properties of each subunit, and the different distribution of brain regions during development, determine the diversity of NMDA receptors in vivo.
The excitatory neurotoxicity of amino acids, especially glutamic acid (Glu) has attracted more and more attention. Glutamate and glutamate receptors participate in excitatory synaptic transmission of neurons, and regulate various forms of learning and memory processes. In Alzheimer's disease and other neurodegenerative diseases, it can be observed that the excitatory response of glutamate is through excessive activation of N-methyl_D-aspartate (NMDA) receptors, thereby making the increase of calcium ions in the cell leads to the death of neurons. Therefore, NMDA receptors may also be a potential target for Alzheimer's disease.
Our Services
- Based on the similarity with natural ligands, we can design targeted inhibitors of NMDA receptors, including high-throughput screening and active compound discovery.
- Provide professional quantum chemistry services. Quantum chemistry is an indispensable tool in drug design research. Our services include QM/MM simulation services, etc.
- Provide GO enrichment analysis service. Our GO enrichment analysis is to classify NMDAR-related differential genes based on GO, and perform significant analysis based on the discrete distribution of the classification results, error rate analysis, and enrichment analysis.
- Provide one-stop molecular docking and molecular dynamics simulation services, including system design, simulation result analysis, and data processing.
- Provide comprehensive biological data management services. We provide professional data management and data analysis services to help customers process various data.
- Provide pathway and network analysis services. We will build a signal pathway regulation network based on the mutual regulation relationship between pathways, and study the signal transduction and regulation process between various signal pathways from a systematic perspective.
- Provide relevant results analysis and data statistics services.
Provided by Clients
Please inform us of the details about your NMDAR targeting research project after signing a non-disclosure agreement, which can be specific to the details of molecular simulation and the requirements for result analysis.
Deliverables
- NMDAR inhibitor design results
- Molecular docking scoring results and other data processing results
- Analysis of molecular dynamics simulation results
- QM/MM simulation result analysis
- GO enrichment analysis results
- Pathway and network analysis results
- Cytocape file: which can be opened by cytoscape for detailed adjustment
Our advantages
- The experiment personnel are skilled and the calculation process is controllable.
- We have professional staff and advanced computational biology platform.
- Our experts have rich experience and can flexibly customize solutions according to different projects.
- Fast and reliable experiment, analysis and delivery speed.
- A complete experimental solution is tailored to save you valuable time and experimental funds.
If you want to know more about NMDAR targeting services provided by CD ComputaBio, please contact us at any time.
* For Research Use Only.
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