A team of scientists from the United States found that by knocking out the MSUT2 gene in mice, it can successfully prevent the formation of Tau protein tangles that kill brain cells and reduce learning and memory problems. According to research, as long as the RNA binding protein PABPN1 (PolyA Binding Protein Nuclear 1) is not "exhausted", inhibiting MSUT2 may protect people from Alzheimer's disease. Under normal circumstances, MSUT2 works closely with PABPN1 to regulate the biology of Tau in the brain. The new study found that if MSUT2 is inhibited without affecting PABPN1, the pathological effects of Tau can be prevented. These results indicate that MSUT2 is expected to become a new target for the development of drugs for Alzheimer's disease. [1]
Our Services
- Use molecular simulations to help determine the impact of small molecules on MSUT2 proteins, and provide help for your drug discovery.
- Combine sequence diagram alignment with multiple structural information to help identify the folding of the target protein in the known template protein structure.
- By optimizing the designed scoring function, the target sequence can be compared with each structural template. Repeat this process for all known 3D structures in the template database until the best fit is found.
- Provide you with conservative sequence analysis services through bioinformatics.
Provided by Clients
Please inform us of the details about your MSUT2 targeting research project after signing a non-disclosure agreement, which can be specific to the force field of molecular dynamics simulation, and the result analysis requirements.
Deliverables
- Raw data of simulation results
- Analysis of protein folding results
- Analysis of protein unfolding results
- Binding free energy calculation results
- Protein homology identification results
- Simulation results, raw data level data processing results
Our advantages
- CD ComputaBio has world-class computational biologists who can help you determine the multi-threaded approach to fusion solutions.
- We often cooperate with many pharmaceutical companies and research institutes, and we can verify structure/sequence matching through energy calculations.
- We have strict quality control on every step of MSUT2 protein calculation to ensure that our customers get high-quality data. You only need the structure of the peptide drug and the receptor. We provide a full range of services from molecular dynamics simulation to result analysis.
If you want to know more about MSUT2 targeting services details provided by CD ComputaBio, please contact us at any time.
Reference:
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Jeanna M. Wheele et al. Activity of thepoly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain. Science Translational Medicine. 2019.
* For Research Use Only.
