Metabolomics, the comprehensive study of metabolic profiles in biological systems, plays a crucial role in understanding cellular processes, disease mechanisms, and the effects of environmental factors on metabolism. At CD ComputaBio, we specialize in providing cutting-edge computational biology services tailored to the field of metabolomics. Our mission is to empower researchers with advanced analytical tools and insights to decode the complexities of metabolic pathways, metabolite interactions, and their roles in biological systems.
Introduction to Metabolomics
Metabolomics is the comprehensive study of metabolites, the small molecules involved in cellular metabolism. These metabolites are the end products of cellular processes and provide a snapshot of the physiological state of an organism. By analyzing metabolites, researchers can gain insights into metabolic pathways, biomarker discovery, and the molecular mechanisms underlying health and disease.
Figure1. The advantages of metabolomics over other omics. (Yu L, et al., 2017)
Methods in Metabolomics
Mass Spectrometry (MS): Mass spectrometry is a powerful technique for metabolite identification and quantification. It offers high sensitivity and specificity, making it a cornerstone of metabolomic analysis.
Nuclear Magnetic Resonance (NMR) Spectroscopy: NMR spectroscopy is another essential technique in metabolomics. It provides detailed information on the structure and dynamics of metabolites and is particularly useful for studying complex mixtures.
Chromatography: Chromatographic techniques, such as gas chromatography (GC) and liquid chromatography (LC), are often coupled with MS or NMR to separate and analyze metabolites. These methods enhance the resolution and accuracy of metabolite detection.
Our Services
Various services are designed to address the diverse challenges of metabolomics research. Our services are tailored to help researchers uncover the intricacies of metabolic pathways, metabolite interactions, and their functional roles in biological systems.
By Substance Types
Lipidomics Metabolomics Service: By leveraging cutting-edge mass spectrometry data, our analysis service can process large-scale datasets to provide a comprehensive understanding of lipid metabolism and signaling pathways. We use machine learning and statistical models to detect patterns and trends through computational analysis of lipid profiles under different treatment conditions.
Amino Acids Metabolomics Service: Amino acids metabolomics service offers in-depth analysis of amino acid metabolites. It employs advanced techniques to precisely profile and quantify these substances, providing valuable insights for research in fields like biology, medicine, and nutrition.
Glycomics Metabolomics Service: By computationally studying glycosylation patterns, we can predict how these patterns affect protein function. By combining glycomic data with proteomics and genomics data, our service can build a more comprehensive view of the molecular mechanisms involved in glycosylation-related biological processes.
Nucleotide Metabolomics Service: In the field of nucleotide analysis, we use advanced method to analyze nucleotide metabolism. Our service process data from various sources, such as metabolomics and genomics experiments, to understand the role of nucleotides in cellular energy and signaling.
By Methods
Untargeted Metabolomics: Untargeted metabolomics can detect and analyzes a wide range of metabolites in samples. Using high-resolution techniques, it uncovers comprehensive metabolic profiles, offering insights for disease research and biomarker discovery.
Targeted Metabolomics: Targeted metabolomics service focuses on specific metabolites. It uses accurate analytical methods to quantify these targeted substances precisely. This helps in in-depth metabolic pathway research and biomarker validation.
Workflow of Metabolomics Service
Preparation: Extraction, internal standards, and derivatization.
Analysis: LC-MS, GC-MS, NMR for separation, identification, and quantification of metabolites.
Data Processing: Metabolite feature extraction, statistical analysis, bioinformatics for disease associations and metabolic signatures.
Our Advantages
Expertise
Our team comprises experienced computational biologists with a deep understanding of metabolomics and data analysis.
Advanced Tools
We utilize the latest computational tools and algorithms to ensure high-quality and reliable results.
Comprehensive Support
From data analysis to interpretation, we provide end-to-end support to help you achieve your research goals.
At CD ComputaBio, we are committed to advancing metabolomics research through innovative computational biology services. Whether you are exploring lipid profiles, glycan structures, nucleotide metabolism, or metabolic fluxes, our expertise and state-of-the-art tools are at your disposal. Partner with us to unlock the full potential of your metabolomics data and drive your research forward. If you are interested in our services or have any questions, please feel free to contact us.
Reference:
- Yu L, Li K, Zhang X. Next-generation metabolomics in lung cancer diagnosis, treatment and precision medicine: mini review. Oncotarget, 2017, 8(70): 115774.
* For Research Use Only.
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