In the field of molecular biology, myocyte enhancer factor 2 (Mef2) protein is a family of transcription factors, which is an important regulator of cell differentiation by controlling gene expression, and therefore plays a key role in embryonic development. In adult organisms, Mef2 protein mediates the stress response of certain tissues. Mef2 protein contains both MADS-box and Mef2 DNA binding domain. MEF2 is a transcription factor with four specific numbers, such as MEF2A, B, C, and D. Each MEF2 gene is located on a specific chromosome
It has been reported that MEF2 expression increases in patients with cognitive flexibility, and may be a valuable target for improving cognitive impairment in patients with neurodegenerative diseases. Researchers have found that cognitive flexibility is highly correlated with the expression of many genes regulated by MEF2 and MEF2, including genes encoding ion channels, which can control the excitability of neurons. In general, the role of MEF2 in promoting cognitive elasticity highlights the potential of MEF2 as a biomarker or therapeutic target for neurodegeneration and healthy aging.
Our Services
- Help you find genes related to MEF2 regulation.
- Analysis of gene network related to MEF2 regulation.
- Related gene co-expression network analysis.
- Related microRNA and target gene network diagram service.
- Related transcription factor analysis and network construction service.
- Provide MEF2 agonist design services to meet your scientific research needs.
- Provide structural optimization and energy minimization services for the selected advantageous ligands.
- Provide molecular dynamics simulation and molecular docking services between agonists and MEF2.
- Choose the appropriate molecular dynamics simulation conditions for you.
- Provide related result analysis service.
Provided by Clients
Please inform us of the details about your MEF2 targeting research project after signing a non-disclosure agreement, which can be specific to the force field of molecular dynamics simulation, and the result analysis requirements.
Deliverables
- The original structure of designed small molecule agonist
- Gene network analysis results
- Gene co-expression network analysis results
- MicroRNA and target gene network diagram results
- Transcription factor analysis results
- Network construction service results
- The initial structure of the simulation system
- Raw data of molecular dynamics results
- Other calculation and analysis results
Our advantages
- CD ComputaBio team members are all experts in computational biology and have rich experience in target calculations.
- We assist clients in completing various research projects. Through experiments and calculations, we provide customers with high-quality target analysis services, help customers publish articles, and recommend scientific research progress.
- Based on high-quality data analysis, the analysis content and methods verified by the pre-research are indeed mature and feasible.
If you want to know more about MEF2 targeting services provided by CD ComputaBio, please contact us at any time.
Reference:
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Barker S.J., Raju R.M., Milman N.E.P., et al. MEF2 is a key regulator of cognitive potential and confers resilience to neurodegeneration. Science Translational Medicine, 2021.
* For Research Use Only.
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