Induced myeloid leukemia cell differentiation protein Mcl-1 is a protein that in humans is encoded by the MCL1 gene. The protein encoded by this gene belongs to the Bcl-2 family. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing. The protein MCL1 has a very short biological half-life of only 20–30 minutes. The loss of MCL1 has a more dramatic impact than the loss of any other anti-apoptotic member of the Bcl-2 family. MCL1 also has a role in the cell's energy production, working in the intermitochondrial space.
It is reported that a powerful mitochondrial autophagy promoter UM1-77 has been discovered. UMI-77 targets MCL-1, which was previously considered a key anti-apoptotic protein. At the same time, MCL-1 is also a mitochondrial autophagy receptor, which can interact with LC3A to promote autonomous mitochondrial bite. More importantly, studies have confirmed that in the APP/PS1 mouse model, mitochondrial autophagy induced by UM1-77 can significantly improve the pathology of Alzheimer's disease (AD).
Our Services
- Provide corresponding protein inhibitors and protein molecular docking services.
- Optimize compounds based on the scaffolds proposed by clients.
- Screen compounds using in silico, high-throughput, and other methods.
- Simulate molecular dynamics between inhibitors and MCL-1 proteins.
- Process data and analyze results using statistical techniques, such as binding affinity analysis, energy analysis and other interaction details analysis.
Provided by Clients
Please inform us of the details about your MCL-1 targeting research project after signing a non-disclosure agreement, which can be specific to the force field of molecular dynamics simulation, and the result analysis requirements.
Deliverables
- MCL-1 molecular dynamics initial structure
- MCL-1 optimized pdb structure
- Molecular dynamics simulation raw data
- Molecular dynamics simulation results analysis raw data
- Molecular dynamics simulation data processing results, icons, results analysis graphs, etc.
Our advantages
- The expert team of CD ComputaBio has a multidisciplinary background, including medicine, pharmacy, molecular biology, bioinformatics, etc. They attach great importance to innovation and practice.
- We have worked with scientists from many pharmaceutical and biotechnology companies. With a special focus on MCL-1, we are committed to contributing to more customers.
- We will complete your project on time according to your scientific research needs. We have a strict quality management system to provide customers with efficient, fast, and reliable solutions.
If you want to know more about MCL-1 target services provided by CD ComputaBio, please contact us at any time.
Reference:
- Cen X, Chen Y, Xu X , et al. Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer's disease mouse model. Nature Communications, 2020, 11(1).
* For Research Use Only.
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