Interleukin 4 (IL-4) is a cytokine that induces naive helper T cells to differentiate into Th2 cells. After being activated by IL-4, Th2 cells subsequently produce additional IL-4 in a positive feedback loop. IL-4 is mainly produced by mast cells, Th2 cells, eosinophils and basophils. Interleukin-4 has many biological roles, including stimulating the proliferation of activated B cells and T cells, and differentiating B cells into plasma cells. It is a key regulator of humoral and adaptive immunity. IL-4 plays an important role in the development of certain immune diseases, especially allergies and some autoimmune diseases. IL-4 has also been shown to drive mitosis, dedifferentiation, and metastasis in rhabdomyosarcoma. IL-4, along with other Th2 cytokines, is involved in the airway inflammation observed in the lungs of patients with allergic asthma. CD ComputaBio now offers professional IL-4 targeting services to meet your research needs.
Our Services
- Flexible Peptide Docking
In the process of target service, the design service of peptide inhibitors and agonists is usually required. CD ComputaBio provides flexible peptide docking services to meet the specific needs of different customers. Flexible docking means that the conformation of the research system can basically be changed freely during the docking process. Generally used to accurately consider identification between molecules. Our flexible peptide docking services do not require specific conformation predictions of peptides.
- Computational Peptide Services
In conjunction with our drug design platform, we offer peptide inhibitor design and construction services. It is important to study the stability and binding affinity of peptide drugs at the computational level, in addition to peptide drug design, we also offer.
- Peptide homology modeling services
- Peptide molecular dynamics simulation
- Peptide molecular docking
- Peptide amino acid interaction network analysis
- Cyclic peptide structure prediction service
- Peptide drug binding affinity calculation service
- Peptide drug energy calculation service
- GSEA analysis
We provide a comprehensive service of GSEA (Gene Set Enrichment Analysis) for determining whether a predefined gene set can show significant consistent differences in two biological states. We first performed a differential screen, using the screened genes (no matter how many) for functional enrichment. No other analysis is required when using GSEA analysis. The advantage is that key information can be preserved, eliminating the need to screen for differences and then finding those functional genomes that are not very different but have consistent genetic differences.
Our Capabilities
CD ComputaBio offers you a complete range of IL-4 targeting services. We have established a complete and professional computing platform. We can help design the details of IL-4 targeting services through rigorous quality control and advanced computational platforms.
Our Pharmacophore Model Construction Service Targeting IL-4
Pharmacophore modeling can help discover key pharmacodynamic characteristics of drug molecules and establish a clear structure-activity relationship. The compound library is virtually screened by the method of pharmacophore to find new scaffold compounds that are active on the target. Pharmacophore can also perform target prediction and predict the pharmacological action spectrum of the compound. By using pharmacophore models, major adverse reactions can be predicted early in drug development, thereby reducing the probability of drug development failure. Our Pharmacophore model construction classifications is as follows:
* For Research Use Only.
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