Hodgkin's Lymphoma

Hodgkin lymphoma (HL) is a lymphoproliferative malignancy of B-cell origin that accounts for 10% of all lymphomas. Based on differences in the morphology and phenotype of the lymphoma cells and the composition of the cellular infiltrate, HL is subdivided into classical Hodgkin lymphoma (cHL) that accounts for about 95% of cases and nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) that accounts for the remaining 5% of cases.

Identification of Hodgkin Lymphoma Predisposing Genes

• Genome sequencing of HL samples.
• Use the SAMtools suite to detect single nucleotide variants (SNVs) and indels.
• Annotate variants using ANNOVAR, 1000 Genomes, dbSNP, and ExAC.
• Data analysis, variant prioritization and validation.
• Use Ingenuity Pathway Analysis software to gain insight into the molecular mechanisms of the pathogenesis of HL.

CD ComputaBio employs unbiased high-throughput sequencing, mass spectrometry and omics data analysis to gain unique insights into cancer evolution, genetics and cell signalling through from premalignancy to metastatic disease. Our work on lymphoma, leukaemia and gastrointestinal cancers, and the creation of computational tools to extract maximum value from Big Data have made big progresses.

In addition, we have multiple resources including academic research and preclinical works in the identification of a suitable disease target and its corresponding hit. Contact us for more service details.

Reference

1. Aayushi Srivastava, et al. Identification of Familial Hodgkin Lymphoma Predisposing Genes Using Whole Genome Sequencing. Frontiers in Bioengineering and Biotechnology. 2020.