Forkhead box protein C2 (FOXC2) also known as forkhead-related protein FKHL14 (FKHL14), transcription factor FKH-14, or mesenchyme fork head protein 1 (MFH1) is a protein that in humans is encoded by the FOXC2 gene. FOXC2 is a member of the fork head box (FOX) family of transcription factors. FOXC2 is involved in cancer metastasis. In particular, the expression of FOXC2 is induced when epithelial cells undergo epithelial-mesenchymal transition (EMT) and become cells with a mesenchymal appearance. EMT can be induced by many genes, including Snail, Twist, Goosecoid, and TGF-beta 1. Overexpression of FOXC2 has been noted in highly metastatic breast cancer subtypes. CD ComputaBio now offers professional FOXC2 targeting services to meet your research needs.
Our Services
- Peptide Molecular Dynamics Simulation
As intrinsic signaling molecules for many physiological functions, peptides offer opportunities for therapeutic interventions that closely mimic natural pathways. CD ComputaBio has extensive experience in peptide drug development, focusing on activity and efficacy studies. We aim to provide you with more services using computational biology methods. CD ComputaBio now provides peptide molecular dynamics simulation services to meet the specific needs of different customers. Our services include but are not limited to:
Molecular docking is a structure-based drug design method that predicts binding mode and affinity by studying the interaction of small-molecule ligands with receptor biomacromolecules. Our structural preparation before docking includes receptor structures and small molecule compounds (libraries); molecular docking calculations include conformation search and scoring evaluation; result analysis services include docking conformation selection, binding mode analysis, scoring and force analysis, etc.
- Bioinformatics Services
Our computational biology platform is equipped with advanced computational instruments and software, and the use of bioinformatics can help to mine and interpret the vast amounts of biological data generated in the recent boom in high-throughput omics research. Our scientists can provide the following services.
- Gene Function Annotation and Function Enrichment Analysis service
- Bioinformatic Analysis-Data Preprocess and Normalization Service
- Bioinformatics Data Management Service
Our Capabilities
CD ComputaBio offers you a complete range of FOXC2 targeting services. We have established a complete and professional computing platform. We can help design the details of FOXC2 targeting services through rigorous quality control and advanced computational platforms.
Our Quantum Chemistry Strategies Targeting FOXC2
- Spectrum Prediction Service
The quantum chemical computing service we provide can simulate and analyze the three-dimensional structure and electron orbital of organic molecules, and predict organic matter. UV, IR and NMR spectroscopy. CD ComputaBio uses the ab initio methods of quantum chemistry in the quantum chemistry package Gauss-ian03. Density functional method (DFT) was used to optimize the stable geometry and electronic structure of the compounds at the B3LYP/6-311g* level. Intrinsic energy can be obtained. The vibration of the corresponding configuration is calculated by the second derivative method of the energy spectrum, and the typical vibration frequency can be analyzed using the quantitative view software Gaussianview.
- Molecular Affinity Calculation Service
CD ComputaBio provides you with services for calculating vertical ionization potential and vertical affinity:
- First optimize the structure of neutral molecules.
- Based on the neutral molecular structure, the same method is used to calculate the single-point energy of +1 valent ions (for calculating ionization energy) or -1 valent ions (for calculating affinity).
- According to the ionization potential or affinity formula, energy is subtracted.
* For Research Use Only.
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