Epigenomics is the study of epigenetic modifications that regulate gene expression without altering the DNA sequence. CD ComputaBio's epigenomics services leverage advanced computational tools and expertise to analyze and interpret epigenomic data. Our goal is to deepen your understanding of epigenetic modifications and their implications in various biological processes and diseases. By integrating advanced computational biology methods with personalized service, we provide comprehensive analyses that support your research endeavors.
Introduction to Epigenomics
Epigenomics is a rapidly evolving field that examines the chemical modifications to DNA and histone proteins that regulate gene expression without altering the underlying genetic code. These modifications include DNA methylation and histone modifications, which play critical roles in cellular differentiation, development, and disease states such as cancer. Understanding these epigenetic mechanisms offers valuable insights into gene regulation and open-up new avenues for diagnostics and therapeutics.
Figure 1. Types of epigenetic changes.
Significance of Epigenomics in Biology
Developmental Regulation
During embryonic development, epigenomic changes are precisely orchestrated. Stem cells differentiate into various cell types like neurons, muscle cells, and liver cells through epigenetic mechanisms. These changes ensure that each cell type expresses the appropriate set of genes for its specific function.
Disease Association
Aberrant epigenomic patterns are linked to many diseases, especially cancer. Tumor suppressor genes can be silenced by abnormal DNA methylation, allowing cancer cells to grow and divide uncontrollably. Understanding these epigenomic changes can lead to new diagnostic and therapeutic strategies.
Our Services
To address the diverse challenges of epigenomic analysis, a comprehensive suite of computational services is offered, covering different types of epigenetic modifications and analysis methods.
By Types
DNA Modification Analysis Service: In the area of epigenomics biology, we provide comprehensive and detailed analysis of DNA methylation patterns. Through sophisticated data alignment, methylation calling, and statistical analysis algorithms, we can quantify DNA methylation levels across the genome.
Histone Modification Analysis Service: CD ComputaBio's histone modification analysis service enables us to map histone modifications across the genome by applying high performance computing. Our service workflow includes data pre-processing, peak calling, and annotation, which helps to accurately identify the genomic locations of histone modifications.
By Methods
ChIP-Seq Service: Using advanced read alignment, peak detection, and motif discovery algorithms, we can accurately identify binding sites for DNA-associated proteins and histone modifications genome-wide. Our computational pipeline is optimized to handle large-scale sequencing data, ensuring high resolution and reliable results.
Chromatin Accessibility Sequencing Service: Assay for transposase-accessible chromatin using sequencing (ATAC-seq) is a fast and sensitive technique that enables the genome-wide profiling of chromatin accessibility. It detects nucleosome-free regions of the genome by using the Tn5 transposome.
Our Advantages
Customized Approaches
Services are adapted to meet specific project requirements, from data processing to functional annotation.
Expert Team
A team of computational biologists, bioinformaticians, and geneticists provides tailored solutions for each project.
Cost-Effective Solutions
High-quality services are provided at competitive prices, reducing the overall cost of research.
CD ComputaBio is dedicated to advancing your research through exceptional epigenomics services. With a strong foundation in computational biology, we provide comprehensive analyses that illuminate the complexities of epigenetic regulation. Whether you are investigating gene regulation, disease mechanisms, or therapeutic strategies, our expertise and tailored services will support you in achieving your research objectives. If you are interested in our services or have any questions, please feel free to contact us.
* For Research Use Only.
Related Services
