CD ComputaBio now offers professional DLL4 targeting services using computational approaches to meet your research needs.
The DLL4 gene provides instructions for making a protein that is part of a signaling pathway called the Notch pathway, which is important for the normal development of many tissues throughout the body. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. The DLL4 protein attaches to a receptor protein called Notch1, chiming together like a key. When a connection is established between DLL4 and Notch1, a series of signaling responses (the Notch pathway) are initiated that affect cell function. In particular, signaling stimulated by DLL4 plays a role in vascular development before birth and in the growth of new blood vessels (angiogenesis) throughout life.
Our Services
Quantitative structure-activity relationship models (QSAR models) are regression or classification models used in chemical and biological science and engineering. Like other regression models, a QSAR regression model associates a set of "predictor" variables (X) with the power of a response variable (Y), while a categorical QSAR model associates the predictor variables with the categorical values of the response variable. The main steps of QSAR/QSPR include:
In the process of target service, the design service of peptide inhibitors and agonists is usually required. CD ComputaBio provides flexible peptide docking services to meet the specific needs of different customers. Flexible docking means that the conformation of the research system can basically be changed freely during the docking process. Generally used to accurately consider identification between molecules. Our flexible peptide docking services do not require specific conformation predictions of peptides. Users simply place peptides near potential binding pockets. The steps of our docking service are as follows:
- Density Functional Theory Calculation Service
Our bioinformaticians will provide our clients with the most accurate density functional theory calculations. Density functional theory (DFT) is a computational quantum mechanical model used in several fields of biochemistry. The properties of a multi-electron system can be determined using a functional, a function of another function. In the case of DFT, these are functionals of the space-dependent electron density. DFT is one of the most popular and versatile methods in condensed matter physics, computational physics, and computational chemistry.
Our Capabilities
CD ComputaBio offers you a complete range of DLL4 targeting services. We have established a complete and professional computing platform. We can help design the details of DLL4 targeting services through rigorous quality control and advanced computational platforms.
Our Molecular Dynamics Analysis Service Targeting DLL4
We can provide a variety of molecular dynamics analysis services. Molecular dynamics (MD) is a computer simulation method used to analyze the physical motion of atoms and molecules. In the most common version, the trajectories of atoms and molecules are determined by numerically solving Newton's equations of motion for interacting particle systems, where the forces between particles and their potential energy are usually calculated mechanically using the electric potential between atoms or molecules force field. This method is mainly used in chemical physics, materials science and biophysics. Our molecular dynamics analysis services include but are not limited to:
* For Research Use Only.
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