CD80 is a member of the B7 family, which consists of molecules present on APCs and their receptors present on T cells. CD80 is specific for DCs, activated B cells and macrophages, and T cells, and CD80 is also a transmembrane glycoprotein and a member of the Ig superfamily. It consists of 288 amino acids and has a mass of 33 kDa. The complex role played by CD80 in immune system regulation provides an opportunity for CD80 interactions to become deregulated in various diseases. Upregulation of CD80 is associated with a variety of autoimmune diseases, including multiple sclerosis, systemic lupus erythematosus, and sepsis (possibly due in part to overactive T cells), and CD80 has also been shown to contribute to the spread of HIV infection in the body.
CD80 has also been implicated in various cancers, although some have experienced CD80-induced tolerance through possible regulatory T cell interactions. CD ComputaBio now offers professional CD80 targeting services to meet your research needs.
Our Services
- Multiple Targeting Drug Design Services
Multiple targeting drugs can effectively modulate complex systems throughout the cell. Multiple targeting drugs can improve the efficacy and safety, act on multiple targets related to the disease, produce a variety of pharmacological activities, obtain the desired diverse biological regulation functions, and reduce side effects. Our multi-target drug solution steps include first detecting cracks or voids on the protein surface, encoding the geometric and physicochemical properties of the voids. Comparisons are then made to find a set of targets with similar cavity properties. Ultimately, multi-target ligands can be designed based on a set of targets with similar cavity characteristics.
- Pathway and Network Analysis
CD ComputaBio will construct a signaling pathway regulatory network based on the mutual regulatory relationship between the pathways in which all differential genes are simultaneously involved, and study the signal transduction and regulation processes between various signaling pathways from a systematic perspective. We can discover core pathways and regulatory mechanisms in important signaling pathways that are affected by experiments.
- Protein Sequence Analysis Service
We can provide you with a wide range of protein sequence analysis services. We provide protein sequence analysis by classifying proteins into protein families and predicting structural domains and significant sites. Our prediction methods include Bayesian network method, support vector machine, Hidden Markov model, artificial neural network method, regression analysis and alignment-free sequence analysis.
Our Capabilities
CD ComputaBio has advanced computing platforms and independent target research groups to provide you with a variety of professional target analysis services. Our scientific research team is large in scale, with multi-disciplinary leading talents in drug research and development, immunology, physiology, biochemistry, etc., forming a technical team mainly with doctoral and master's degrees. CD ComputaBio can provide you with a cost-effective one-stop solution.
Our Computational Peptide Strategies Targeting CD80
In recent years, peptide drugs have been developed and used in clinical practice. Due to the wide range of indications, high safety and remarkable efficacy, it is very important to study the stability and binding affinity of peptide drugs at the computational level. We offer a range of computational peptide services to suit your research needs, you can choose according to your needs. In addition to designing small molecule inhibitors for you, we can also provide peptide inhibitor design services, follow-up peptide molecular dynamics simulation and result analysis services. Specifically, our computational peptide services include but are not limited to:
* For Research Use Only.
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