BAFF is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. As an immunostimulator, BAFF (BLyS, TALL-1) is required for the maintenance of normal immunity. BAFF is a 285 amino acid long peptide glycoprotein that is glycosylated at residue 124. It is expressed as a membrane-bound type II transmembrane protein on various cell types, including monocytes, dendritic cells, and bone marrow stromal cells. The transmembrane form can be cleaved from the membrane, yielding soluble protein fragments. Steady-state concentrations of BAFF depend on B cells and the expression of BAFF-bound receptors. Insufficient levels of BAFF will fail to activate B cells to produce sufficient immunoglobulins and lead to immunodeficiency. Excessive BAFF levels can lead to abnormally high antibody production, leading to systemic lupus erythematosus, rheumatoid arthritis, and many other autoimmune diseases. CD ComputaBio now offers professional BAFF targeting services to meet your research needs.
Our Services
- In Silico Protein-Protein Interactions Prediction
Protein-protein interactions (PPIs) are highly specific physical contacts established between two or more protein molecules, including electrostatic forces, hydrogen bonds, and hydrophobic effects. Proteins rarely act alone because their functions are often regulated. We can accurately predict protein interactions based on different aspects. The services we provide mainly include:
- PPI Interaction Prediction
- PPI Interaction Network Prediction
- PPI Interaction Site Prediction
- Protein Sequence Analysis Service
CD ComputaBio can provide you with professional protein sequence analysis services. We provide protein sequence analysis by classifying proteins into protein families and predicting domains and important sites. Our methods include：
- Bayesian network method
- Support Vector Machines
- Hidden Markov Model
- Artificial neural network
- Regression analysis
- Pairless sequence analysis
- QM/MM Simulation Service
Hybrid quantum mechanics/molecular mechanics (QM/MM) simulations have become a popular tool for studying condensed-phase chemical reactions. In the QM/MM approach, the regions of the system where chemical processes take place are treated at an appropriate level of quantum chemical theory, while the rest are described by molecular mechanics force fields. High-precision QM/MM calculation is a multi-scale calculation method for studying ligand binding. Modeling time can be greatly reduced by characterizing proteins and solvents using quantum chemistry representing ligands combined with molecular mechanics. Our bioinformaticians will provide you with the most efficient quantum chemistry services.
Our Capabilities
CD ComputaBio has advanced computing platforms and independent target research groups to provide you with a variety of professional target analysis services. Our scientific research team is large in scale, with multi-disciplinary leading talents in drug research and development, immunology, physiology, biochemistry, etc., forming a technical team mainly with doctoral and master's degrees. CD ComputaBio can provide you with a cost-effective one-stop solution.
Our Antibody Drug Discovery Strategies Targeting BAFF
Now, CD ComputaBio offers antibody drug discovery services to meet the specific needs of different clients. Antibody drugs are an important aspect of the biotech pharmaceutical field. Antibodies have the specificity to recognize antigens, so the use of antibodies to diagnose and treat diseases is a long-term goal of medical researchers. The binding of antibodies to target antigens is highly specific, effective and safe, and is clinically used in various major diseases such as malignant tumors and autoimmune diseases. Our services include but are not limited to:
* For Research Use Only.
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