Activating transcription factor 5, also known as ATF5, is a protein encoded by the ATF5 gene in humans. ATF5 has been classified as a member of the activating transcription factor ( ATF )/cAMP response element binding protein ( CREB ) family. ATF5 transcripts and proteins are expressed in a variety of tissues, especially the transcript is highly expressed in the liver. It is also present in a variety of tumor cell types. ATF5 expression is regulated at both the transcriptional and translational levels. ATF5 is expressed in VZ and SVZ during brain development. The human ATF5 protein consists of 282 amino acids. ATF5 is a transcription factor containing a bZip domain. CD ComputaBio now offers professional ATF-5 targeting services to meet your research needs.
Our Services
- Correlation Analysis
Correlation analysis refers to the analysis of two or more related variable elements to measure the closeness of two variable factors. CD ComputaBio recognizes similar characteristics to known biomarkers. In this case, the researcher is looking for a feature (metabolite or peak) to indicate that its intensity or concentration change is similar to the target feature (co-expression). We can directly correlate target features to identify those peaks or metabolites that are positively or negatively correlated. Hierarchical clustering methods can also be used. Elements in the same cluster as the target element are most similar in intensity or concentration change.
- Hydrogen Bond Analysis Service
The hydrogen atom is covalently bonded to the atom X with high electronegativity. If it is close to the atom Y (OFN, etc.) with high electronegativity and small radius, hydrogen is used as the medium between X and Y to generate the form of XH…Y A special type of intermolecular or intramolecular interaction known as hydrogen bonding. In molecular dynamics simulations, hydrogen bonding calculations are very important and can help to study the details of the interaction between the target and small molecules. CD ComputaBio provides corresponding hydrogen bond analysis services to meet your research needs.
- Umbrella Sampling Simulation Service
CD ComputaBio can provide you with umbrella sampling simulation technology. Umbrella potentials involve only a few degrees of freedom, often referred to as collective variables or reaction coordinates. A system sample is considered complete when the system "visits" all the values of the set variable multiple times (that is, the number of times required to make an accurate and unbiased calculation of the state probability). Umbrella sampling is a very popular technique for calculating mean force (PMF) to study protein binding-unbinding processes. Later, the binding free energy can also be extracted from the obtained PMF.
Our Capabilities
CD ComputaBio has extensive expertise and extensive experience in research on target computing. We have built a comprehensive and complex computational biology platform. Our mission is to provide reliable and high-quality services, providing strong support to our clients in target calculation and evaluation.
Our Protein-Protein Interactions Prediction Service Targeting ATF-5
CD ComputaBio can provide you with protein interaction prediction services through a number of different methods. A protein-protein interaction (PPI) is a highly specific physical contact established between two or more protein molecules, which is the results of biochemical events, including electrostatic forces, hydrogen bonding, and hydrophobic effects. Many are physical contacts of molecular associations between chains that occur in cells in a specific biomolecular environment or in living organisms. Proteins rarely act alone because their functions are often regulated. We can accurately predict protein interactions based on different aspects. The services we provide mainly include:
* For Research Use Only.
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