The armadillo repeat protein deleted in velo-cardio-facial syndrome is a protein encoded by the ARVCF gene in humans. The armadillo repeat gene deleted in Velo-Cardio-Facial syndrome (ARVCF) is a member of the catenin family, which plays an important role in the formation of the adhesion junction complex and is thought to facilitate communication between the intracellular and extracellular environments. The ARVCF gene was isolated in the search for a genetic defect that causes autosomal dominant Velo-Cardio-Facial syndrome (VCFS), a relatively common human disorder that includes cleft palate, pyramidal heart defects, and Phenotypic features including facial deformities. The protein encoded by the ARVCF gene contains two motifs, an N-terminal coiled-coil domain and a 10-armadillo repeat mid-region sequence. Since these sequences can facilitate protein-protein interactions, ARVCF is thought to function in protein complexes. Furthermore, ARVCF contains a predicted nuclear targeting sequence, suggesting that it may function as a nuclear protein. CD ComputaBio now offers professional ARVCF targeting services to meet your research needs.
Our Services
- Quantum Chemistry Service
Quantum chemistry is an indispensable tool in drug design. High-throughput computer screening of small molecule drug combinations can significantly reduce the time required for compound discovery and optimization. Our quantum chemical computing services include:
- QM/MM Simulation
High-precision QM/MM calculation is a multi-scale calculation method for studying ligand binding. Modeling time can be greatly reduced by characterizing proteins and solvents using quantum chemistry representing ligands combined with molecular mechanics.
- Density Functional Theory Calculation
The essence of density functional theory is to convert wave function into electron density function as the basic unit of research. Our density functional service can simplify the calculation process of NTRK target research.
- High Throughput Screening
High-throughput screening technology is an important research topic in the field of drug screening. Our screening service can provide customers with a variety of drug screening services. We have established relatively mature screening models in multiple disease research fields, including new high-throughput preliminary screening models and in-depth screening at various levels.
- Drug Design Services
Based on computational chemistry, it helps you design and optimize lead compounds through computer simulations, calculations and predictions of relationships between drugs and receptor biomolecules. Our drug design services will include:
Our Capabilities
CD ComputaBio has specialized target analysis experts. You only need to briefly describe your service needs, and our experts will provide you with customized solutions and communicate with you about service details. We have successfully supported multiple target analysis services. Our team is committed to providing customers with a full range of target computing support and services.
The advantage of multi-targeted drug design technology is to provide new ideas for new drug research and development, make full use of the structural information of known compounds, avoid the waste of research and development resources to a certain extent, and speed up the research and development of new drugs. drug development. It has strong feasibility and broad development prospects, and may become an important tool for new drug research and development. The multi-target drug design service process begins by detecting cracks or voids on the protein surface, encoding the geometry and physicochemical properties of the voids. Comparisons are then made to find a set of targets with similar cavity properties. Ultimately, multi-target ligands can be designed based on a set of targets with similar cavity characteristics.
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