Applications of DAVID Software

The Database for Annotation, Visualization, and Integrated Discovery (DAVID) provides researchers with a comprehensive set of functional annotation tools to understand the biological meaning behind a large number of genes. DAVID consists of four main modules: Annotation Tool, GoCharts, KeggCharts, and DomainCharts. These tools are powered by a comprehensive DAVID knowledge base built on the DAVID gene concept, which brings together multiple sources of functional annotation. DAVID is a biological information database that integrates biological data and analysis tools to provide systematic and comprehensive biological function annotation information for the large-scale gene or protein lists (lists of hundreds or thousands of gene IDs or protein IDs), helping users to extract biological information. DAVID speeds up the functional annotation and analysis of any gene list encoded by the human, mouse, rat, or drosophila genome.

Our Services Based on DAVID Software

In bioinformatics analysis, we often carry out KEGG and GO enrichment analysis, which generally need to be realized by R language or DAVID software. On the DAVID software platform, CD ComputaBio can provide the listed services:

• GO Enrichment Analysis
  CD ComputaBio provides GO enrichment analysis, including significant function enrichment analysis of mRNA, to obtain significant, targeted functions and target genes corresponding to significant functions.
• KEGG Enrichment Analysis
  KEGG enrichment analysis is a routine data mining method based on gene function. CD ComputaBio often uses KEGG enrichment analysis for gene function studies and key gene screening of differential gene sets.
• Gene ID Conversion
  CD ComputaBio uses this software to map various protein/gene IDs into gene identifiers and symbols. For example, find the respective gene symbols for Ensembl gene lists, or convert human UniProt protein sequences to HGNC gene IDs and symbols.
• Pathway Enrichment Analysis
  Through the pathway analysis of differential genes, our scientists can obtain the significant and targeted pathways involved in all genes related to the mainstream expression trend. And they identified the cellular pathways associated with differential genes in different samples, and mapped the downregulated differential genes to each pathway map to locate key genes in key pathways.

Our Capabilities

CD ComputaBio has a professional bioinformatics team to guide genome, transcriptome and epigenome metadata analysis solutions. We help you perform insightful data analysis and interpretation to understand the results of your experiments in the context of various biological systems. The analysis services are not limited to sequencing data quality control, annotation, alternative splicing analysis, evaluation, differential expression analysis.

Features of DAVID Software

• Gene Similarity Search
  Any given gene is associated with a set of annotation terms. If genes share a similar set of terms, they are likely to involve similar biological mechanisms. The algorithm attempts to group those related genes according to the agreement of the Kappa statistic to share similarly annotated terms.
• Term Similarity Search
  If two or more biological processes are performed by a similar set of genes, then these processes may be related in some way in a biological network. This search function identifies related biological processes/terms by quantitatively measuring the degree of agreement on how the terms share similar participating genes.