Anaplastic lymphoma kinase (ALK) was first discovered in anaplastic large cell lymphoma (ALCL) cells in 1994. ALCL is caused by a (2;5) (p23: q35) chromosomal translocation that produces the fusion protein NPM-ALK, in which the kinase domain of ALK is fused to the amino-terminal portion of the nucleophosmin (NPM) protein. ALK is a mesenchymal lymphoma kinase, and in 2007 scientists first discovered the existence of transforming active EML4-ALK gene rearrangement in lung cancer, a gene rearrangement that can contribute to lung carcinogenesis and progression. Positive ALK gene rearrangements are present in approximately 3-5% of all non-small cell lung cancers, which may seem like a low percentage, although ALK expression rates in young, non-smoking and EGFR-unmutated lung adenocarcinoma patients can be as high as 25%-30%. The incidence of ALK fusion is higher in mucinous or solid adenocarcinomas with pathological types containing imprinted cells, reaching 46.2%. Now, CD ComputaBio offers professional ALK targeting services to meet your research needs.
Our Services
- Drug Design Services
Based on computational chemistry, it helps you design and optimize lead compounds through computer simulations, calculations and predictions of relationships between drugs and receptor biomolecules. Our drug design services will include:
- Feasibility assessment of drug targets.
- High throughput screening and active compound discovery based on structural design.
- Discovery of active compounds for lead compounds.
- Optimization of lead compounds to identify drug candidates.
- Computer-aided drug design.
- Structure-effect relationship studies.
- Computational Peptide Services
In conjunction with our drug design platform, we offer peptide inhibitor design and construction services. It is important to study the stability and binding affinity of peptide drugs at the computational level, in addition to peptide drug design, we also offer.
- Peptide homology modeling services
- Peptide molecular dynamics simulation
- Peptide molecular docking
- Peptide amino acid interaction network analysis
- Cyclic peptide structure prediction service
- Peptide drug binding affinity calculation service
- Peptide drug energy calculation service
- Protein Sequence Analysis Service
We can provide you with a wide range of protein sequence analysis services. We provide protein sequence analysis by classifying proteins into protein families and predicting structural domains and significant sites. Our prediction methods include Bayesian network method, support vector machine, Hidden Markov model, artificial neural network method, regression analysis and alignment-free sequence analysis.
Our Capabilities
CD ComputaBio has specialized target analysis experts. You only need to briefly describe your service needs, and our experts will provide you with customized solutions and communicate with you about service details. We have successfully supported multiple target analysis services. Our team is committed to providing customers with a full range of target computing support and services.
Our Network Analysis Strategies Targeting ALK
- Residue Interaction Network Service
RIN analysis can provide a complex analysis of ALK targets and their complexes. Estimates about their interdependence allow predicting the different properties and functions of individual residues and whole proteins. We construct RINs to analyze the energy of target and small molecule compound interactions.
- PPI Network Service
Providing PPI network analysis can help you delve into the details of the interaction of peptide inhibitors or protein drugs with ALK targets. PPI network analysis is the establishment of highly specific physical contacts between two or more protein molecules, and these interactions include electrostatic forces, hydrogen bonding and hydrophobic interactions. This information can create large protein interaction networks that resemble metabolic or genetic/epigenetic networks, which can enhance existing knowledge of the biochemical cascades of disease and molecular etiology, and enable discovery of therapeutically meaningful targets.
Project Sample
Our computational biology team has extensive experience in the research of ALK targets. The following is a small snapshot of our research process for reference only. For details, please feel free to consult our professional team.
* For Research Use Only.
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